Springfield has White River Brewing, Tie and Timber, 4x4 brewing, Mother's. Springfield Brewing company, and I think one more. There is also a distillery at Copper Run (about 10 miles out of Branson) and another distillery in downtown Springfield called Missouri Spirits.
I've not been to Tie And Timber or 4x4 but my friends like both. White River has some great ones and Mother's tap room is always good. Both of the distillery's are outstanding.
Also a TON of original music in Springfield. Hit up Commercial St. and got to White River Brewing and Moon City Pub and Lindberg's and eat at Pizza House or Cafe Cusco.